William H. Howell Professor
Molecular & Integrative Physiology
Expertise: Laboratory seeks to identify and investigate genetic mechanisms that are likely to be important for aging and age-related disease in humans by focusing on equivalent, conserved processes in the fruit fly, Drosophila melanogaster. Currently studying biological pathways involved in sensory perception, neural reward circuits, and reproductive and mating behaviors.
Professor of Internal Medicine
Expertise: Research interests have focused on identifying new mechanisms and targets in heart failure, with a particular interest in noncoding RNA pathways. In this context, the laboratory has identified novel pathways that are functionally important in the heart’s response to both pathological and physiological stimuli. The lab has had a longstanding interest in understanding how exercise protects against cardiovascular disease and how this interacts with aging.
Executive Vice President for Medical Affairs
Dean, University of Michigan Medical School
CEO, University of Michigan Health System
Expertise: Research has focused on translating basic science observations in cardiovascular biology to animal models, and ultimately, to clinical care. Innovations include the generation of and testing of fibrin-specific plasminogen activators for treatment of acute MI, and establishing the role of cellular- and mitochondrial-derived oxidative stress in aging and atherogenesis and development of preventive therapies.
Research Assistant Professor
Expertise: The Salmon Laboratory is interested in molecular and epigenetic mechanisms surrounding Aortic Aneurysm growth and rupture. Specific interests include zinc-finger epigenetic regulation of smooth muscle cells and fibroblasts in the context of Aortic Aneurysms and RNA post-transcriptional epigenetic modifications on Aneurysm progression and rupture. Therapeutically, the Salmon lab seeks to develop a medical treatment therapy to halt progression or prevent rupture in Aortic Aneurysms.
Henry King Ransom Professor
Expertise: Dr. Seeley’s lab focuses on basic research on the biological systems that regulate food intake, body weight and metabolism. The lab works to identify new therapies for obesity and diabetes.
Expertise: Understanding the influence of diet-induced obesity on hematopoiesis and the generation of macrophages that promote metabolic disease.
Metabolism, Endocrinology & Diabetes (MEND)
Expertise: The role of mitochondrial quality control in pancreatic beta cell function and diabetes.
Expertise: Characterizing cardiac phenotypes in murine models of disease. Expert at assessing how epigenetic factors regulate gene expression profiles and cardiac phenotypes.
Internal Medicine - Cardiovascular Medicine
Expertise: Expertise: Genetic Cardiomyopathies, Chemical Biology, Molecular Chaperones, Cardiac Critical Care. Our research program is interested in using chemical biology tools to understand molecular perturbations driving the pathogenesis of cardiomyopathies. We are particularly interested in understanding the influence of environmental stressors and aging.
Expertise: The long-term goal of the Wang laboratory is to develop heart therapies to effectively prolong and improve the life of heart patients. The Wang lab has focused on epigenetic mechanisms of cardiac cell metabolism, cardiac progenitor differentiation and reprogramming, and development of novel strategies for heart repair and regeneration. A recent research direction is to connect directly the energy metabolism and epigenetics for heart therapy.
Jeffrey B. Halter Collegiate Professor of Geriatric Medicine
Chief, Division of Geriatric and Palliative Medicine
Director, Geriatrics Center
Director, Institute of Gerontology
Internal Medicine - Geriatrics and Palliative Medicine
Expertise: Metabolic Factors and Inflammation (T cells, dendritic cells, and chemokine system); Predisposing Factors (epigenetics and diet); and Age-related Diseases/Comorbidities (cardiovascular disease, cancer, obesity, arthritis).
Expertise: Developing and application of statistical methods for biomedical research in areas including, but not limited to, cardiac surgery/cardiovascular disease, kidney disease, diabetics, organ transplantation, cancer and genetics. Extensive experience on working with data of various types (e.g., clustered/multilevel, longitudinal, survival) and obtained from both observational studies (e.g., clinical registries, health claims data) and clinical trials.