Biological Chemistry
Expertise: Transcription regulatory networks
Assistant Professor
Internal Medicine
Expertise: Received his training in cardiovascular disease as well as advanced heart failure and cardiac transplantation at the University of Michigan. Research focuses on the underlying pathophysiology of heart failure with preserved ejection fraction. One of two cardiologists that staffs the Heart Failure with Preserved Ejection Fraction Clinic at the CVC.
Frederick G. L. Huetwell Collegiate Professor of Basic Research
Internal Medicine - Cardiovascular Medicine
Molecular & Integrative Physiology
Expertise: Laboratory studies role of proteases and their inhibitors in health and disease. Primary areas of interest = vascular biology of the CNS (a), and on the development of peripheral vascular and fibrotic disease (b). The principal targets of this work are members of the serine protease inhibitor (serpin) family of proteins, their target proteases, and their downstream protease substrates. Long standing interest aimed at understanding how these proteins drive vascular and fibrotic disease processes.
Associate Professor
Molecular & Integrative Physiology
Internal Medicine
Expertise: The lab studies stress response pathways and their relationship to health and longevity. Research utilizes multiple animal models to identify conserved factors related to stress resistance and aging, focusing on the mechanistic and signaling relationship between stress and longevity.
Professor of Pediatrics and Communicable Diseases
Professor of Molecular and Integrative Physiology
Pediatrics and Communicable Diseases
Expertise: The Lumeng Lab studies adipose tissue inflammation in the context of obesity, age, and cardiometabolic disease. The lab focuses on the complex adipose tissue immune system that contributes to metabolic dysregulation and disruption of adipocyte function.
Research Scientist
Internal Medicine
Division of Cardiovascular Medicine
Expertise: Redox signaling, NADPH oxidases, VSMC biology, Aging, Atherosclerosis
Clinical Professor of Medicine
Internal Medicine, Infectious Diseases
Expertise: Device associated infections, surgical infections, peri-operative care of older adults.
Internal Medicine
Molecular and Integrative Physiology
Expertise: Research laboratory is interested in molecular mechanisms of inherited cardiomyopathies and muscle diseases. Experimentally use molecular approaches, live cell imaging and whole animal physiology to study how the function of striated muscle is altered by gene mutations that result in defective interactions of muscle cells with the extracellular matrix and disrupted cytoskeleton/sarcomeric architecture.
Expertise: Laboratory makes mice that age slowly because of diet, drug treatment, or mutation, and tries to figure out why they are so long-lived. Also study cell biology of fibroblasts, in culture, derived from long- and short-lived species of rodents, birds and primates.
Amanda Sanford Hickey Professor of Internal Medicine
Associate Division Chief, Clinical and Translational Research
Associate Director of Translational Research, Geriatrics Center
Internal Medicine, Division of Geriatric and Palliative Medicine
Expertise: Leads an active translational research laboratory focused on defining the clinical and molecular epidemiology of antimicrobial resistant pathogens in post-acute and long-term care facilities and developing measures to prevent their spread.
Andre Monteiro Da Rocha, Ph.D.
Research Assistant Professor
Internal Medicine
Expertise: Goal is to develop a strong research program on cardiac aging that will contribute to understanding of how the time-associated accumulation of changes/damages to heart cells occurs and how they can be mitigated to promote healthier aging and better life quality.
Molecular & Integrative Physiology
Internal Medicine - Endocrine
Expertise: The Mortensen lab is interested in understanding the roles that immune cells have in the pathophysiology of disease. They use a combination of pharmacological and genetic techniques to probe the cellular signaling mechanisms and metabolic effects that regulate immune cells during the disease process. Lab focuses on cardiac disease, stroke, obesity and diabetes.
Learning Health Sciences
Expertise: Medical education; program evaluation; palliative care education; faculty development
Assistant Professor
Internal Medicine - Metabolism, Endocrinology & Diabetes
Expertise: Research focuses on the impact of age and comorbidity on thyroid cancer and benign thyroid disease decision making, the overtreatment with and misuse of thyroid hormone in older adults and subsequent skeletal, cardiovascular and cognitive effects in aging individuals, and the roles of the physician and patient in the management of thyroid disorders across the age spectrum.
Ruth Professor and Chief, Cardiovascular Medicine
Director, Samuel and Jean Frankel Cardiovascular Center
Internal Medicine
Expertise: Laboratory focused on understanding how natural blood vessel defense mechanisms may be amplified to protect in conditions such as stroke, heart attack, or organ transplantation. Work focuses on protective enzyme which lines blood vessels, amplifying a natural defense mechanism against unchecked inflammation and coagulation.