Expertise: Cardiovascular system dynamics, cardiac energy metabolism, computer modeling and simulation
Associate Professor of Medicine
Expertise: Interested in the aging-associated kidney function decline with focus on glomerulopathy associated with aging.
Internal Medicine - Cardiovascular Medicine
Expertise: The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression with specific interest in understanding how intracellular signal transduction in cardiomyocytes is compartmentalized and regionally controlled by lipid modifications to modulate cardiac physiology and pathogenesis. They utilize a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms.
Robert C. and Veronica Atkins Professor of Metabolism
Professor of Internal Medicine
Professor of Molecular & Integrative Physiology
Nutritional Sciences (SPH)
Expertise: Personal research program centers on the interaction between genetics and environmental factors in the development of insulin resistance, obesity and β-cell failure in both man and in animal models. Specific interest in intermediary metabolism and how mitochondrial fuel selection and efficiency play a role in cellular aging. Laboratory combines clinical phenotyping with metabolomics, lipidomics, epigenomics and gene expression profiling to understand how metabolism is modulated in an individual.
Y. Eugene Chen, M.D., Ph.D.
Frederick Huetwell Professor
Expertise: Research program in vascular medicine is elucidating the molecular basis of diabetes-induced and dyslipidemia-associated cardiovascular diseases (CVD), and developing new drugs and technologies to study and treat diabetes and CVD.
Biology, UM-Flint Campus
Expertise: Trained as a nutritional immunologist - lab investigates differential metabolism of nutrients by immune cells. Specifically, lab focuses on regulation of dendritic cell metabolism of vitamin A, vitamin D, and omega 3 fatty acids.
Expertise: Interested in understanding the fundamental molecular motions and interactions that are responsible for regulating calcium transport in cardiac muscle cells, and designing effective molecular therapies to treat human diseases associated with dysregulation of calcium transport in the heart - approaching these multidisciplinary problems with a combination of multiscale computational methods and experimental techniques.
Edward B. Diethrich M.D. Professor of Biomedical Engineering and Vascular Surgery
Expertise: 1. Computational modeling of hemodynamics using medical image data. 2. Aortic Disease 3. Non-invasive diagnostics of coronary artery disease
Research Assistant Professor
Expertise: Cellular and molecular mechanisms of inflammation and diabetes in obesity and in aging. Epigenetics of cellular senescence and molecular basis of cardiovascular diseases in aging.
Eliza Maria Mosher Collegiate Professor of Internal Medicine
Research Professor, Institute of Gerontology
Director, Michigan Biology of Cardiovascular Aging (M-BoCA)
Expertise: Aging and inflammation; atherosclerosis; aging and immunity
Expertise: The Greve Lab is driven by the biological question. They provide novel answers by developing robust and reproducible preclinical MRI techniques and applying engineering principles. Therapeutically, the Greve Lab is interested in the use of exercise to stimulate intrinsic therapeutic pathways to treat CV disease (leveraging the ‘internal pharmacy’, as described by others).
Director, Cardiovascular Regeneration Core Laboratory
Associate Research Scientist
Molecular & Integrative Physiology
Expertise: Laboratory focuses on utilizing patient specific induced pluripotent stem cells to generate cardiovascular cell types. These cells are used for Drug Discovery projects, for toxicity testing, for creating personalized "disease in a dish" models and for regenerative medicine applications.
Clinical Associate Professor
Expertise: Interested in vascular inflammation as it relates to atherosclerosis and aortic aneurysms. Laboratory studies the role of S100/calgranulins and their receptor RAGE in mouse models of atherosclerosis, vascular calcification and calcific aortic valve disease. Recent studies explored foam cell formation of smooth muscle cells in response to modified LDL lipoproteins.
Internal Medicine - Cardiology
Expertise: Complex signaling mechanisms, which regulate platelet function, hemostasis and thrombosis. Platelet research from basic science and drug discovery program in eicosanoids and lipoxygenases to projects including clinical trial focused on platelet function in type 2 diabetes mellitus, clinical studies on racial disparity in platelet activation and thrombotic risk, identification of novel bioactive lipids in platelet, development of first-in-human inhibitors for prevention of thrombosis and stroke.
Internal Medicine - Cardiovascular Medicine
Expertise: Research focuses on how dietary factors affect development and progression of heart failure with preserved ejection fraction, specific interest in vascular inflammation and metabolic disarray as important mechanisms. Directs the Heart Failure with Preserved Ejection Fraction Clinic at the CVC and is the site and/or principal investigator for several investigator-initiated and industry funded clinical trials. Co-chairs the Research Group of the American College of Cardiology’s Geriatric Section.