Faculty

Professor
Director, Michigan Biology of Cardiovascular Aging (M-BoCA)
Internal Medicine - Cardiovascular Medicine
Ahmed Abdel-Latif is a clinician-scientist interested in basic and translational research studies focused on the molecular and cellular mechanisms of pathological cardiac remodeling. His lab explores the immune response to myocardial injury and stress, and its effect on adverse cardiac remodeling. To this goal, his research integrates biochemical, cellular, and pharmacological methods to examine the role of bone marrow-derived innate immune cells in cardiac recovery after injury.
Expertise: Interventional Cardiology, Cardiovascular Disease
Professor
Expertise: Minimally invasive valve surgery, minimally invasive mitral surgery, percutaneous therapies, aortic aneurysm surgery, aortic root/David procedure and Hypertrophic obstructive cardiomyopathy (HOCM)
Professor
Physiology
Expertise: Cardiovascular system dynamics, cardiac energy metabolism, computer modeling and simulation
Associate Professor of Medicine
Internal Medicine
Expertise: Interested in the aging-associated kidney function decline with focus on glomerulopathy associated with aging.
Assistant Professor
Pharmacology
Internal Medicine - Cardiovascular Medicine
Expertise: The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression with specific interest in understanding how intracellular signal transduction in cardiomyocytes is compartmentalized and regionally controlled by lipid modifications to modulate cardiac physiology and pathogenesis. They utilize a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms.
Robert C. and Veronica Atkins Professor of Metabolism
Professor of Internal Medicine
Professor of Molecular & Integrative Physiology
Nutritional Sciences (SPH)
Expertise: Personal research program centers on the interaction between genetics and environmental factors in the development of insulin resistance, obesity and β-cell failure in both man and in animal models. Specific interest in intermediary metabolism and how mitochondrial fuel selection and efficiency play a role in cellular aging. Laboratory combines clinical phenotyping with metabolomics, lipidomics, epigenomics and gene expression profiling to understand how metabolism is modulated in an individual.
Frederick Huetwell Professor
Internal Medicine
Cardiac Surgery
Expertise: Research program in vascular medicine is elucidating the molecular basis of diabetes-induced and dyslipidemia-associated cardiovascular diseases (CVD), and developing new drugs and technologies to study and treat diabetes and CVD.
Associate Professor
Internal Medicine
Expertise: Interested in understanding the fundamental molecular motions and interactions that are responsible for regulating calcium transport in cardiac muscle cells, and designing effective molecular therapies to treat human diseases associated with dysregulation of calcium transport in the heart - approaching these multidisciplinary problems with a combination of multiscale computational methods and experimental techniques.
Edward B. Diethrich M.D. Professor of Biomedical Engineering and Vascular Surgery
Biomedical Engineering
Vascular Surgery
Expertise: 1. Computational modeling of hemodynamics using medical image data. 2. Aortic Disease 3. Non-invasive diagnostics of coronary artery disease
Eliza Maria Mosher Collegiate Professor of Internal Medicine
Research Professor, Institute of Gerontology
Internal Medicine-Cardiovascular Medicine
Expertise: Aging and inflammation; atherosclerosis; aging and immunity
Director, Cardiovascular Regeneration Core Laboratory
Associate Research Scientist
Internal Medicine
Molecular & Integrative Physiology
Expertise: Laboratory focuses on utilizing patient specific induced pluripotent stem cells to generate cardiovascular cell types. These cells are used for Drug Discovery projects, for toxicity testing, for creating personalized "disease in a dish" models and for regenerative medicine applications.
Clinical Professor
Internal Medicine
Expertise: Thoracic Aortic aneurysm and dissection, clinical translational research for aortic aneurysm, Director for the FCVC biobank (CHIP), Co-Director for MiAorta Network. Interested in vascular inflammation mediated by S100/calgranulins and their receptor RAGE as it relates to atherosclerosis and aortic aneurysms.
Associate Professor
Pharmacology
Internal Medicine - Cardiology
Expertise: Complex signaling mechanisms, which regulate platelet function, hemostasis and thrombosis. Platelet research from basic science and drug discovery program in eicosanoids and lipoxygenases to projects including clinical trial focused on platelet function in type 2 diabetes mellitus, clinical studies on racial disparity in platelet activation and thrombotic risk, identification of novel bioactive lipids in platelet, development of first-in-human inhibitors for prevention of thrombosis and stroke.
Assistant Professor
Internal Medicine - Cardiovascular Medicine
Expertise: Research focuses on how dietary factors affect development and progression of heart failure with preserved ejection fraction, specific interest in vascular inflammation and metabolic disarray as important mechanisms. Directs the Heart Failure with Preserved Ejection Fraction Clinic at the CVC and is the site and/or principal investigator for several investigator-initiated and industry funded clinical trials. Co-chairs the Research Group of the American College of Cardiology’s Geriatric Section.
Maurice H. Seevers Professor and Chair of Pharmacology
Professor of Molecular and Integrative Physiology
Professor of Neurology
Pharmacology
Expertise: Mechanisms of epileptic encephalopathy and cardiac arrhythmias linked to mutations in voltage-gated sodium channel genes; mechanisms of sudden unexpected death in epilepsy (SUDEP); ion channel structure and function; transgenic mouse models of neurological and cardiac disease; patient-derived induced pluripotent stem cell neurons and cardiac myocytes.

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